![]() Resultsĩ9mTc-anti-RAGE F(ab’) 2 SPECT/CT imaging demonstrated increased lung expression of RAGE with smoke exposure compared to room air control at 4-weeks: Room air right (R) 0.75 ± 0.38%ID, left (L) 0.62 ± 0.32%ID vs. Lungs were dissected for gamma well counting and histological analysis. Lung radiotracer uptake was calculated as percent injected dose (%ID). MethodsĪfter exposure to room air or to cigarette smoke for 4-weeks or 16-weeks, rabbits were injected with 99mTc-anti-RAGE F(ab’) 2 and underwent Single-Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) imaging. We hypothesized that RAGE directed imaging demonstrates increased lung uptake in smoke-exposure. ![]() ![]() ![]() Expression of the Receptor for Advanced Glycation Endproducts (RAGE) initiates pro-inflammatory pathways resulting in lung destruction. ![]()
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